Title : Divergent Roles of CYP26B1 and Endogenous Retinoic Acid in Mouse Fetal Gonads.

Pub. Date : 2019 Sep 26

PMID : 31561560






3 Functional Relationships(s)
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1 Retinoic acid (RA) is considered the main inducer of meiotic entry, as it stimulates Stra8 which is required for the mitotic/meiotic switch. Tretinoin stimulated by retinoic acid gene 8 Mus musculus
2 Retinoic acid (RA) is considered the main inducer of meiotic entry, as it stimulates Stra8 which is required for the mitotic/meiotic switch. Tretinoin stimulated by retinoic acid gene 8 Mus musculus
3 Collectively, our data reveal that CYP26B1 has other activities apart from metabolizing RA in fetal gonads and suggest a role of endogenous RA in amplifying Stra8, rather than being the initial inducer of Stra8. Tretinoin stimulated by retinoic acid gene 8 Mus musculus