Title : Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies.

Pub. Date : 2019 Nov 14

PMID : 31554636






1 Functional Relationships(s)
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1 Additionally, the HRI-eIF2alphaP-ATF4 pathway represses mechanistic target of rapamycin complex 1 (mTORC1) signaling, specifically in the erythroid lineage as a feedback mechanism of erythropoietin-stimulated erythropoiesis during iron/heme deficiency. Sirolimus activating transcription factor 4 Homo sapiens