Title : Perinatal nicotine exposure alters Akt/GSK-3β/mTOR/autophagy signaling, leading to development of hypoxic-ischemic-sensitive phenotype in rat neonatal brain.

Pub. Date : 2019 Dec 1

PMID : 31553625






1 Functional Relationships(s)
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1 Treatment with mTOR inhibitor rapamycin effectively blocked nicotine-mediated autophagy deficiency and more importantly, reversed nicotine-induced increase in HI brain infarction. Sirolimus mechanistic target of rapamycin kinase Rattus norvegicus