Pub. Date : 2019
PMID : 31551774
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The MDCK cellular research results showed that, among nine predominant ingredients of MHT, L-methylephedrin (LMEP), L-ephedrine (LEP) and D-pseudo- ephedrine (DPEP) significantly inhibited the proliferation of influenza A virus in vitro, and the inhibitory effect at 24 h after the treatment was more obvious than that at 48 h. They also significantly inhibited the mRNA expression levels of related genes in the TLR3, TLR4 and TLR7 signaling pathways, which were accompanied with the down-regulation of TNF-alpha level and the up-regulation of IFN-beta level in the cell supernatant. | Ephedrine | tumor necrosis factor | Homo sapiens |
| 2 | The MDCK cellular research results showed that, among nine predominant ingredients of MHT, L-methylephedrin (LMEP), L-ephedrine (LEP) and D-pseudo- ephedrine (DPEP) significantly inhibited the proliferation of influenza A virus in vitro, and the inhibitory effect at 24 h after the treatment was more obvious than that at 48 h. They also significantly inhibited the mRNA expression levels of related genes in the TLR3, TLR4 and TLR7 signaling pathways, which were accompanied with the down-regulation of TNF-alpha level and the up-regulation of IFN-beta level in the cell supernatant. | Ephedrine | tumor necrosis factor | Homo sapiens |
| 3 | The MDCK cellular research results showed that, among nine predominant ingredients of MHT, L-methylephedrin (LMEP), L-ephedrine (LEP) and D-pseudo- ephedrine (DPEP) significantly inhibited the proliferation of influenza A virus in vitro, and the inhibitory effect at 24 h after the treatment was more obvious than that at 48 h. They also significantly inhibited the mRNA expression levels of related genes in the TLR3, TLR4 and TLR7 signaling pathways, which were accompanied with the down-regulation of TNF-alpha level and the up-regulation of IFN-beta level in the cell supernatant. | Ephedrine | tumor necrosis factor | Homo sapiens |
| 4 | Animal research further indicated, at the 3rd and 7th days after infection, LEP and DPEP significantly attenuated lung injury, decreased lung index, virus load in the lung and the level of IL-1beta in serum, inhibited the mRNA expression levels of TNF-alpha, TLR3, TLR4, TLR7, MyD88, NF-kappaB p65 and RIG-1 as well as the protein expression levels of TLR4, TLR7, MyD88 and NF-kappaB p65 and markedly increased thymus index, the level of IL-10 in serum and the mRNA expression level of IFN-gamma. | Ephedrine | tumor necrosis factor | Homo sapiens |