Title : Pharmacokinetic Drug-Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects.

Pub. Date : 2020 Mar

PMID : 31542894






2 Functional Relationships(s)
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1 To evaluate whether organic cation transporter (OCT) 1, OCT2 and multidrug and toxin extrusion (MATE) 1 and MATE2-K are involved in pharmacokinetics, competitions with ranitidine, a probe inhibitor of the cation transporters, were evaluated in transfected HEK293 cells. Ranitidine solute carrier family 22 member 1 Homo sapiens
2 Ranitidine inhibited OCT1, OCT2, MATE1, and MATE2-K with half maximal inhibitory concentration values of 186 +- 25 microM, 482 +- 105 microM, 134 +- 37 microM, and 35 +- 11 microM, respectively. Ranitidine solute carrier family 22 member 1 Homo sapiens