Title : DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide.

Pub. Date : 2019 Nov 15

PMID : 31542479






2 Functional Relationships(s)
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1 Here we found that the expression of dihydrofolate reductase (DHFR) and thymidylate synthetase (TYMS), which played an essential role in folate metabolism and several types of tumors, were up-regulated in both human glioma tissues and cell lines, and overexpression of DHFR/TYMS promoted the proliferation of glioma cells. Folic Acid dihydrofolate reductase Homo sapiens
2 Here we found that the expression of dihydrofolate reductase (DHFR) and thymidylate synthetase (TYMS), which played an essential role in folate metabolism and several types of tumors, were up-regulated in both human glioma tissues and cell lines, and overexpression of DHFR/TYMS promoted the proliferation of glioma cells. Folic Acid dihydrofolate reductase Homo sapiens