Pub. Date : 2020 Jan
PMID : 31536662
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previously, we demonstrated that two new TSPO ligands named 2a and 2b, stimulated pregnenolone synthesis and ATP production in a cellular model of AD overproducing beta-amyloid peptide. | Pregnenolone | translocator protein | Homo sapiens |
| 2 | The present study evaluates the impact of the new TSPO ligands on mitochondrial dysfunction in a cellular model of AD-related tauopathy (human neuroblastoma cells SH-SY5Y stably overexpressing the P301L-mutant Tau) presenting mitochondrial impairments including a decreased ATP synthesis and mitochondrial membrane potential as well as a decrease in pregnenolone synthesis when compare to control cells. | Pregnenolone | translocator protein | Homo sapiens |
| 3 | The TSPO ligands 2a and 2b exerted beneficial mitochondrial modulatory effects by increasing ATP levels and mitochondrial membrane potential, paralleled with an increase of pregnenolone levels in mutant Tau cells as well as in control cells. | Pregnenolone | translocator protein | Homo sapiens |