Title : Hormonal regulation of expression of the endogenous and transfected human growth hormone gene.

Pub. Date : 1987 Aug

PMID : 3153479






2 Functional Relationships(s)
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1 Insulin alone or in combination with T3 or Dex was found to increase hGH mRNA levels in some cell lines and to decrease hGH mRNA levels in others; these effects were correlated strongly (r = 0.88; P less than 0.001) with the influence of insulin on the endogenous rat GH gene, implying that individual cellular differences can simultaneously affect the insulin responsiveness of both genes. Triiodothyronine insulin Homo sapiens
2 Insulin alone or in combination with T3 or Dex was found to increase hGH mRNA levels in some cell lines and to decrease hGH mRNA levels in others; these effects were correlated strongly (r = 0.88; P less than 0.001) with the influence of insulin on the endogenous rat GH gene, implying that individual cellular differences can simultaneously affect the insulin responsiveness of both genes. Triiodothyronine insulin Homo sapiens