Title : Prostaglandin E2 induces DNA hypermethylation in gastric cancer in vitro and in vivo.

Pub. Date : 2019

PMID : 31534549






1 Functional Relationships(s)
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1 We retrospectively analyzed the 5mC content of 42 patients with intestinal metaplasia (a precancerous lesion of GC) treated with a COX-2 specific inhibitor Rofecoxib or placebo for 2 years, revealing that the COX-2 inhibitor significantly down-regulated 5mC levels (N=42, P=0.009). rofecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens