Pub. Date : 2019 Nov
PMID : 31521892
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P-glycoprotein (P-gp) is one of the important transporters that mediate MTX resistance. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | P-glycoprotein (P-gp) is one of the important transporters that mediate MTX resistance. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | This study investigated the effect of Paeoniflorin-6"-O-benzene sulfonate (code: CP-25) in the resistance of P-gp-mediated MTX to RA. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Besides, P-gp high expression of human hepatoma cell line Bel7402/5-FU and Bel7402 were chose to study in MTX resistance and the function of P-gp was detected by Flow cytometry. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | CONCLUSION: CP-25 regulates the expression of P-gp and inhibits the function of P-gp, thereby improving the resistance of MTX. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |