Title : Multivalency-assisted membrane-penetrating siRNA delivery sensitizes photothermal ablation via inhibition of tumor glycolysis metabolism.

Pub. Date : 2019 Dec

PMID : 31521887






1 Functional Relationships(s)
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1 Due to its multivalent topology, DPP exhibited stronger membrane activity yet lower cytotoxicity than its linear analogue (LPP), thus enabling efficient PKM2 silencing in MCF-7 cells in vitro (~75%) and in vivo (~70%). dipalmitoylphosphatidylserine pyruvate kinase M1/2 Homo sapiens