Pub. Date : 2020 Feb
PMID : 31518438
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BTK inhibitors synergize with 5-FU to treat drug-resistant TP53-null colon cancers. | Fluorouracil | tumor protein p53 | Homo sapiens |
| 2 | Using drug-resistant TP53-null colon cancer cells as a model we demonstrated that p65BTK silencing or chemical inhibition overcame the 5-fluorouracil resistance of CRC cell lines and patient-derived organoids and significantly reduced the growth of xenografted tumours. | Fluorouracil | tumor protein p53 | Homo sapiens |