Title : Annurca apple polyphenol extract selectively kills MDA-MB-231 cells through ROS generation, sustained JNK activation and cell growth and survival inhibition.

Pub. Date : 2019 Sep 10

PMID : 31506575






1 Functional Relationships(s)
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1 Moreover, downregulation of JNK by its specific inhibitor SP600125 significantly diminished the anticancer activity of APE indicating that ROS generation and sustained JNK activation represented the main underlying mechanism of APE-induced cell death. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens