Title : Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban.

Pub. Date : 2019 Nov

PMID : 31506301






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1 Retrospective drug-drug interaction (DDI) simulations, incorporating in vitro metabolic inhibitory parameters, accurately recapitulated clinically observed attenuation of rivaroxaban"s hepatic clearance due to enzyme-mediated DDIs with CYP3A4/2J2 inhibitors (verapamil and ketoconazole). Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens