Pub. Date : 2019
PMID : 31502430
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibiting PKC and ERK with respectively calphostin C and PD98059 abolished the effect of FTY720-P on the ATPase and on IkappaB, but not that of exogenous PGE2 indicating that the two kinases are upstream of NF-kappaB and PGE2. | FTY 720P | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | CONCLUSION: It was concluded that FTY720-P stimulates the Na+/K+ ATPase via PGE2 by activating sequentially S1PR3, PKC, ERK, NF-kappaB. | FTY 720P | mitogen-activated protein kinase 1 | Homo sapiens |