Pub. Date : 2019 Sep 7
PMID : 31500291
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Distinct TP53 Mutation Subtypes Differentially Influence Cellular Iron Metabolism. | Iron | tumor protein p53 | Homo sapiens |
| 2 | The most commonly mutated gene in all human cancers is the tumor suppressor gene TP53; however, in addition to the loss of tumor suppressor functions, mutations in TP53 can also promote cancer progression by altering cellular iron acquisition and metabolism. | Iron | tumor protein p53 | Homo sapiens |
| 3 | The most commonly mutated gene in all human cancers is the tumor suppressor gene TP53; however, in addition to the loss of tumor suppressor functions, mutations in TP53 can also promote cancer progression by altering cellular iron acquisition and metabolism. | Iron | tumor protein p53 | Homo sapiens |
| 4 | The primary objective of this work was to determine how TP53 mutation status influences the molecular control of iron homeostasis. | Iron | tumor protein p53 | Homo sapiens |
| 5 | The introduction of distinct TP53 mutation types alone was sufficient to disrupt cellular iron metabolism. | Iron | tumor protein p53 | Homo sapiens |
| 6 | In response to changes in iron availability, cells harboring either a wild-type TP53 or R273H TP53 mutation displayed canonical IRP-mediated responses, but neither IRP1 RNA binding activity nor IRP2 protein levels were affected by changes in iron status in cells harboring the R175H mutation type. | Iron | tumor protein p53 | Homo sapiens |
| 7 | In response to changes in iron availability, cells harboring either a wild-type TP53 or R273H TP53 mutation displayed canonical IRP-mediated responses, but neither IRP1 RNA binding activity nor IRP2 protein levels were affected by changes in iron status in cells harboring the R175H mutation type. | Iron | tumor protein p53 | Homo sapiens |
| 8 | These findings suggest a novel, IRP-independent mode of iron regulation in cells expressing distinct TP53 mutations. | Iron | tumor protein p53 | Homo sapiens |