Title : Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells.

Pub. Date : 2019 Sep 5

PMID : 31491956






2 Functional Relationships(s)
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1 Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression. Lycopene nuclear factor kappa B subunit 1 Homo sapiens
2 Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression. Lycopene nuclear factor kappa B subunit 1 Homo sapiens