Pub. Date : 2019
PMID : 31482012
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously reported that p53-mediated apoptosis is determined by severity of DNA damage, not by the level of p53, in doxorubicin-treated prostate cancer cells. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 2 | By using dominant negative p53 to compete with wild-type p53 in transcription activity, we demonstrated that p53-mediated apoptosis in response to doxorubicin- or camptothecin-induced genotoxic stress is transcription-independent. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 3 | By using dominant negative p53 to compete with wild-type p53 in transcription activity, we demonstrated that p53-mediated apoptosis in response to doxorubicin- or camptothecin-induced genotoxic stress is transcription-independent. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 4 | By using dominant negative p53 to compete with wild-type p53 in transcription activity, we demonstrated that p53-mediated apoptosis in response to doxorubicin- or camptothecin-induced genotoxic stress is transcription-independent. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 5 | Interestingly, we also found that doxorubicin-induced p21 expression is activated by p53 in transcription-dependent manner, while camptothecin-induced p21 expression is p53-independent. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 6 | We then investigated the p53 ratio of nucleus to cytosol corresponding to low and high dose doxorubicin, camptothecin, or bortezomib treatment. | Doxorubicin | tumor protein p53 | Homo sapiens |