Title : From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction.

Pub. Date : 2019 Nov 15

PMID : 31476557






1 Functional Relationships(s)
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1 By exploiting the power of multicomponent chemistry, a relatively small, diverse set of primary sulfonamides was synthesized and screened against a panel of human carbonic anhydrases to reveal a low-nanomolar, albeit non-selective hCA IV lead inhibitor. Sulfonamides carbonic anhydrase 4 Homo sapiens