Title : JmjC domain-containing protein 8 (JMJD8) represses Ku70/Ku80 expression via attenuating AKT/NF-κB/COX-2 signaling.

Pub. Date : 2019 Dec

PMID : 31473257






2 Functional Relationships(s)
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1 We also provided evidence to show that knockdown of JMJD8 up-regulated cyclooxygenase-2 (COX-2) expression which contributed to the enhanced expression of Ku70/Ku80 as shown by the results that pre-treatment of JMJD8 knockdown cells with COX-2 selective inhibitor NS-398 inhibited the induction of Ku70/Ku80. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide prostaglandin-endoperoxide synthase 2 Homo sapiens
2 We also provided evidence to show that knockdown of JMJD8 up-regulated cyclooxygenase-2 (COX-2) expression which contributed to the enhanced expression of Ku70/Ku80 as shown by the results that pre-treatment of JMJD8 knockdown cells with COX-2 selective inhibitor NS-398 inhibited the induction of Ku70/Ku80. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide prostaglandin-endoperoxide synthase 2 Homo sapiens