Pub. Date : 2020 Jan
PMID : 31469975
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upstream and serving as an activator of IL-1ss lies the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome that has been well described in animal models to be activated by cholesterol crystals or hypoxia to promote cleavage and secretion of IL-1ss and IL-18 that lead to atherosclerotic deposition in arteries. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Upstream and serving as an activator of IL-1ss lies the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome that has been well described in animal models to be activated by cholesterol crystals or hypoxia to promote cleavage and secretion of IL-1ss and IL-18 that lead to atherosclerotic deposition in arteries. | Cholesterol | NLR family pyrin domain containing 3 | Homo sapiens |