Title : The beta adrenergic receptor antagonist propranolol alters mitogenic and apoptotic signaling in late stage breast cancer.

Pub. Date : 2019 Jun

PMID : 31466709






2 Functional Relationships(s)
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1 RESULTS: Neoadjuvant propranolol decreased expression of the pro-proliferative Ki-67 and pro-survival Bcl-2 markers, and increased pro-apoptotic p53 expression in a patient with stage III breast cancer. Propranolol tumor protein p53 Homo sapiens
2 Furthermore, propranolol treatment of breast cancer cells increased p53 levels, enhanced caspase cleavage, and induced apoptosis. Propranolol tumor protein p53 Homo sapiens