Pub. Date : 1988 Oct
PMID : 3146595
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of theophylline infusion on the growth hormone (GH) and prolactin response to GH-releasing hormone administration in acromegaly. | Theophylline | growth hormone 1 | Homo sapiens |
| 2 | Since theophylline has been shown to blunt the GH response to growth hormone-releasing hormone (GHRH) in normal subjects, we investigated whether the same effect of theophylline administration could be reproduced in patients with active acromegaly. | Theophylline | growth hormone 1 | Homo sapiens |
| 3 | However, the amount of GH released after GHRH stimulation was lower when theophylline was concomitantly infused (7525 +/- 3709 ng min/ml vs. 12038 +/- 6337 ng min/ml; p less than 0.05). | Theophylline | growth hormone 1 | Homo sapiens |
| 4 | Our results demonstrate that in active acromegaly theophylline blunts the GH response to GHRH, though this effect is not uniformly seen in all patients. | Theophylline | growth hormone 1 | Homo sapiens |