Title : CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.

Pub. Date : 2019 Nov

PMID : 31455676






1 Functional Relationships(s)
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1 Expression of CYP3A4 and metabolism of triazolam, a typical CYP3A substrate, in the liver of CYP3A/PXR-humanized mice were enhanced in response to rifampicin, a typical human PXR activator. Rifampin nuclear receptor subfamily 1, group I, member 2 Mus musculus