Title : Rapidly quantitative analysis of γ-glutamyltranspeptidase activity in the lysate and blood via a rational design of the molecular probe by matrix-assisted laser desorption ionization mass spectrometry.

Pub. Date : 2019 Dec 1

PMID : 31450413






2 Functional Relationships(s)
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1 The function of anthraquinone part is not only to increase molecular mass of the target ions after GGT catalyzed cleavage enabling the report ions appearing in higher m/z region avoiding matrix ion interference, but also to remarkably enhance the report ions ionization efficiency. Anthraquinones inactive glutathione hydrolase 2 Homo sapiens
2 Under optimized conditions, when employing an Aq linked methylated-glutathione (Aq-ECA) as the internal standard, the GGT activity amount can be quantified in a linear range of 1-50 U/L with r2 > 0.99. Anthraquinones inactive glutathione hydrolase 2 Homo sapiens