Title : Hypothesis: Metabolic targeting of 5-aminolevulinate synthase by tryptophan and inhibitors of heme utilisation by tryptophan 2,3-dioxygenase as potential therapies of acute hepatic porphyrias.

Pub. Date : 2019 Oct

PMID : 31443750






2 Functional Relationships(s)
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1 Metabolic targeting of liver 5-aminolevulinate synthase (5-ALAS) by inhibition of heme utilisation by tryptophan (Trp) 2,3-dioxygenase (TDO) or the use of tryptophan is proposed as a therapy of acute hepatic porphyrias. Tryptophan 5'-aminolevulinate synthase 1 Rattus norvegicus
2 Tryptophan is also proposed as a potential therapy of acute attacks either alone or as an adjunct to the recently proposed 5-ALAS1 gene silencing. Tryptophan 5'-aminolevulinate synthase 1 Rattus norvegicus