Title : Cannabidiol attenuates the rewarding effects of cocaine in rats by CB2, 5-HT1A and TRPV1 receptor mechanisms.

Pub. Date : 2020 May 1

PMID : 31437433






2 Functional Relationships(s)
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1 Strikingly, this reduction in both cocaine self-administration and BSR was blocked by AM630 (cannabinoid CB2 receptor antagonist), WAY100135 (5-HT1A receptor antagonist), or capsazepine (TRPV1 channel blocker), but not by AM251 (CB1 receptor antagonist), CID16020046 (GPR55 antagonist), or naloxone (opioid receptor antagonist), suggesting the involvement of CB2, 5-HT1A, and TRPV1 receptors in CBD action. Cocaine 5-hydroxytryptamine receptor 1A Rattus norvegicus
2 Strikingly, this reduction in both cocaine self-administration and BSR was blocked by AM630 (cannabinoid CB2 receptor antagonist), WAY100135 (5-HT1A receptor antagonist), or capsazepine (TRPV1 channel blocker), but not by AM251 (CB1 receptor antagonist), CID16020046 (GPR55 antagonist), or naloxone (opioid receptor antagonist), suggesting the involvement of CB2, 5-HT1A, and TRPV1 receptors in CBD action. Cocaine 5-hydroxytryptamine receptor 1A Rattus norvegicus