Pub. Date : 2019 Sep
PMID : 31436536
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that in a human CAR (hCAR)-knockout (KO) HepaRG cell line, PB significantly induces the expression of CYP2B6 and CYP3A4, two shared target genes of hCAR and human PXR (hPXR). | Phenobarbital | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In human primary hepatocytes and hCAR-KO HepaRG cells, PB-induced expression of CYP3A4 was markedly repressed by genetic knockdown or pharmacological inhibition of hPXR. | Phenobarbital | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |