Pub. Date : 2019 Sep 23
PMID : 31434716
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that human importin-alpha1 is regulated during the cell cycle and is phosphorylated at two sites (threonine 9 and serine 62) during mitosis by the major mitotic protein kinase CDK1-cyclin B. Mutational analysis indicates that the mitotic phosphorylation of importin-alpha1 inhibits its binding to importin-beta and promotes the release of TPX2 and KIFC1, which are then targeted like importin-beta to the spindle. | Threonine | cyclin dependent kinase 1 | Homo sapiens |