Pub. Date : 1988 Dec 2
PMID : 3142689
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Binding of the human transcription factor Jun/AP-1 to a conserved 8 bp nucleotide sequence (TRE) is responsible for increased transcription of different cellular genes in response to tumor promoters, such as TPA, and serum factors. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Enhanced Jun/AP-1 activity in TPA-stimulated cells is regulated by two different mechanisms: a posttranslational event acting on pre-existing Jun/AP-1 molecules, and transcriptional activation of jun gene expression leading to an increase in the total amount of Jun/AP-1. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | Enhanced Jun/AP-1 activity in TPA-stimulated cells is regulated by two different mechanisms: a posttranslational event acting on pre-existing Jun/AP-1 molecules, and transcriptional activation of jun gene expression leading to an increase in the total amount of Jun/AP-1. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 4 | Enhanced Jun/AP-1 activity in TPA-stimulated cells is regulated by two different mechanisms: a posttranslational event acting on pre-existing Jun/AP-1 molecules, and transcriptional activation of jun gene expression leading to an increase in the total amount of Jun/AP-1. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 5 | Induction of jun transcription in response to TPA is mediated by binding of Jun/AP-1 to a high-affinity AP-1 binding site in the jun promoter region. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 6 | Induction of jun transcription in response to TPA is mediated by binding of Jun/AP-1 to a high-affinity AP-1 binding site in the jun promoter region. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 7 | Site-specific mutagenesis of this binding site prevents TPA induction and trans-activation by Jun/AP-1. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |