Title : Rapid antidepressant actions of imipramine potentiated by zinc through PKA-dependented regulation of mTOR and CREB signaling.

Pub. Date : 2019 Oct 15

PMID : 31420165






3 Functional Relationships(s)
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1 Rapid antidepressant actions of imipramine potentiated by zinc through PKA-dependented regulation of mTOR and CREB signaling. Imipramine cAMP responsive element binding protein 1 Homo sapiens
2 Combination of zinc with imipramine rapidly enhanced the phosphorylation of mTOR Ser2448 and CREB Ser133, and increased the expression of mTOR and CREB, which were dependent on the activation of PKA. Imipramine cAMP responsive element binding protein 1 Homo sapiens
3 Combination of zinc with imipramine rapidly enhanced the phosphorylation of mTOR Ser2448 and CREB Ser133, and increased the expression of mTOR and CREB, which were dependent on the activation of PKA. Imipramine cAMP responsive element binding protein 1 Homo sapiens