Title : Copper-Mediated Selenazolidine Deprotection Enables One-Pot Chemical Synthesis of Challenging Proteins.

Pub. Date : 2019 Oct 7

PMID : 31408267






2 Functional Relationships(s)
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Protein Name
Organism
1 The seleno-analog Se-TSTD1, in which the active site Cys is replaced with selenocysteine, was also synthesized with a kinetically controlled ligation with an N-to-C synthetic approach. Cysteine thiosulfate sulfurtransferase like domain containing 1 Homo sapiens
2 The catalytic activity of the two proteins indicated that Se-TSTD1 possessed only four-fold lower activity than WT-TSTD1, thus suggesting that selenoproteins can have physiologically comparable sulfutransferase activity to their cysteine counterparts. Cysteine thiosulfate sulfurtransferase like domain containing 1 Homo sapiens