Title : Interleukin-1β inhibits estrogen receptor-α, progesterone receptors A and B and biomarkers of human endometrial stromal cell differentiation: implications for endometriosis.

Pub. Date : 2019 Oct 28

PMID : 31408162






2 Functional Relationships(s)
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Protein Name
Organism
1 Inhibition of the extracellular signal-regulated kinase (ERK)1/2 pathway by a selective pharmacological blocker (PD98059) or siRNA interference, or the addition of hormones themselves, blocked phosphorylation of ERK mediators, increased the production of steroid receptors, Cx43, prolactin, insulin-like growth factor binding protein (IGFBP)-1 and vascular endothelial growth factor (VEGF) and accelerated differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens
2 Inhibition of the extracellular signal-regulated kinase (ERK)1/2 pathway by a selective pharmacological blocker (PD98059) or siRNA interference, or the addition of hormones themselves, blocked phosphorylation of ERK mediators, increased the production of steroid receptors, Cx43, prolactin, insulin-like growth factor binding protein (IGFBP)-1 and vascular endothelial growth factor (VEGF) and accelerated differentiation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens