Pub. Date : 2019 Nov
PMID : 31401678
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A5 and CYP3A7 genetic polymorphisms affect tacrolimus concentration in pediatric patients with nephrotic range proteinuria. | Tacrolimus | cytochrome P450 family 3 subfamily A member 7 | Homo sapiens |
| 2 | PURPOSE: The purpose of this study was to investigate the potential impact of CYP3A4, CYP3A5, and CYP3A7 polymorphisms on the concentration and efficacy of tacrolimus in a cohort of pediatric patients with nephrotic range proteinuria. | Tacrolimus | cytochrome P450 family 3 subfamily A member 7 | Homo sapiens |
| 3 | The CYP3A7 rs2257401 was also associated with the concentration of tacrolimus. | Tacrolimus | cytochrome P450 family 3 subfamily A member 7 | Homo sapiens |
| 4 | In addition, there were significant differences in tacrolimus concentration among CYP3A7 rs10211 G carriers and non-carriers; the latter had an almost twofold C0 of the former (101.8 vs 59.6, P = 0.0004). | Tacrolimus | cytochrome P450 family 3 subfamily A member 7 | Homo sapiens |
| 5 | CONCLUSIONS: Our study demonstrated the associations between CYP3A5*3, CYP3A7 rs2257401 and rs10211, and tacrolimus concentration in pediatric patients with nephrotic range proteinuria. | Tacrolimus | cytochrome P450 family 3 subfamily A member 7 | Homo sapiens |
| 6 | Children with CYP3A5*3 A, CYP3A7 rs2257401 C, and rs10211 G alleles might need a higher dose of tacrolimus. | Tacrolimus | cytochrome P450 family 3 subfamily A member 7 | Homo sapiens |