Title : Dysregulated expression of ACTN4 contributes to endothelial cell injury via the activation of the p38-MAPK/p53 apoptosis pathway in preeclampsia.

Pub. Date : 2019 Nov

PMID : 31399951






1 Functional Relationships(s)
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1 Downregulation of ACTN4 by siRNA or H2O2 treatment promoted normotensive HUVEC apoptosis and increased p38-MAPK phosphorylation along with elevated levels of p53 phosphorylation, caspase cascade proteins, and bax and repressed expression of bcl-2. Hydrogen Peroxide mitogen-activated protein kinase 14 Homo sapiens