Pub. Date : 2019
PMID : 31396402
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhanced ROS generation by pristimerin activated the ASK1/JNK signaling pathway. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Inhibition of ROS with N-acetyl cysteine (NAC) significantly decreased pristimerin-induced cell death by inhibiting the phosphorylation of ASK1 and JNK. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Taken together, these results suggest a critical role for the ROS/ASK1/JNK pathway in the anticancer activity of pristimerin. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |