Title : Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.

Pub. Date : 2019 Jul

PMID : 31392261






3 Functional Relationships(s)
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1 Two key interaction points required for RET extracellular domain binding were observed: (i) the calcium-binding site in RET that contacts GFRalpha2 domain 3 and (ii) the RET cysteine-rich domain interaction with NRTN. Calcium ret proto-oncogene Homo sapiens
2 Two key interaction points required for RET extracellular domain binding were observed: (i) the calcium-binding site in RET that contacts GFRalpha2 domain 3 and (ii) the RET cysteine-rich domain interaction with NRTN. Calcium ret proto-oncogene Homo sapiens
3 Two key interaction points required for RET extracellular domain binding were observed: (i) the calcium-binding site in RET that contacts GFRalpha2 domain 3 and (ii) the RET cysteine-rich domain interaction with NRTN. Calcium ret proto-oncogene Homo sapiens