Title : Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme.

Pub. Date : 2019 Aug 7

PMID : 31391279






3 Functional Relationships(s)
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1 This observation contrasts with the existence in T. brucei of a dimeric deoxyuridine 5"-triphosphate nucleotidohydrolase (dUTPase), an essential enzyme that can produce dUMP via the hydrolysis of dUTP/dUDP. 2'-deoxyuridylic acid Deoxyuridine triphosphatase Drosophila melanogaster
2 Thus, T. brucei dUTPase-null mutants are thymidine auxotrophs, suggesting that dUTPase might have a role in providing dUMP for thymidylate biosynthesis. 2'-deoxyuridylic acid Deoxyuridine triphosphatase Drosophila melanogaster
3 Thus, T. brucei dUTPase-null mutants are thymidine auxotrophs, suggesting that dUTPase might have a role in providing dUMP for thymidylate biosynthesis. 2'-deoxyuridylic acid Deoxyuridine triphosphatase Drosophila melanogaster