Pub. Date : 2019 Aug 6
PMID : 31387985
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | By RNA interference and ectopic Hic-5 expression, we demonstrated Hic-5 was essential for activation of NADPH oxidase and ROS generation leading to activation of downstream JNK and c-jun transcription factor. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
2 | Thus Hic-5 was both downstream and upstream of NADPH oxidase-ROS-JNK-c-jun cascade. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |