Title : Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiency.

Pub. Date : 2019 Aug

PMID : 31383553






2 Functional Relationships(s)
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1 We previously showed that oral treatment of the Tk2 H126N knock-in mouse model (Tk2-/-) with the TK2 substrates, deoxycytidine (dCtd) and thymidine (dThd), delayed disease onset and prolonged median survival by 3-fold. Deoxycytidine thymidine kinase 2, mitochondrial Mus musculus
2 We previously showed that oral treatment of the Tk2 H126N knock-in mouse model (Tk2-/-) with the TK2 substrates, deoxycytidine (dCtd) and thymidine (dThd), delayed disease onset and prolonged median survival by 3-fold. Deoxycytidine thymidine kinase 2, mitochondrial Mus musculus