Title : Disulfiram facilitates ataxin-3 nuclear translocation and potentiates the cytotoxicity in a cell model of SCA3.

Pub. Date : 2019

PMID : 31378764






2 Functional Relationships(s)
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Protein Name
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1 The nuclear presence of polyglutamine-expanded ataxin-3 is of critical importance for the pathogenesis of SCA3. polyglutamine ataxin 3 Homo sapiens
2 To our knowledge, this is direct evidence that disulfiram elevated the nuclear localization of polyglutamine-expanded ataxin-3 and enhanced the cytotoxicity in a cell model of SCA3. polyglutamine ataxin 3 Homo sapiens