Title : Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins.

Pub. Date : 2019 Nov

PMID : 31377397






1 Functional Relationships(s)
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1 Replacement of F28 with other aromatic residues like tyrosine and tryptophan preserves protein stability while replacement with non-aromatic amino acids like leucine, isoleucine, valine or alanine severely affects the stability of SHIP1. Leucine inositol polyphosphate-5-phosphatase D Homo sapiens