Title : PKCĪ“ Mediates Mineralocorticoid Receptor Activation by Angiotensin II to Modulate Smooth Muscle Cell Function.

Pub. Date : 2019 Sep 1

PMID : 31373631






3 Functional Relationships(s)
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1 AngII activation of MR was blocked by the MR antagonist spironolactone or eplerenone and the protein kinase C-delta (PKCdelta) inhibitor rottlerin, implicating both in the mechanism. rottlerin angiotensinogen Homo sapiens
2 The impact of AngII on FKBP51 reporter activity and gene expression in SMCs was inhibited by spironolactone and rottlerin. rottlerin angiotensinogen Homo sapiens
3 Finally, the AngII-induced increase in SMC number was also blocked by the MR antagonist spironolactone and the PKCdelta inhibitor rottlerin. rottlerin angiotensinogen Homo sapiens