Title : Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism.

Pub. Date : 2019

PMID : 31369604






1 Functional Relationships(s)
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1 Inhibiting RhoA/rho kinase (ROCK) with Y27632 (10 muM) suppressed contractions to U46619 and phenylephrine by ~80% and prevented their inhibition by simvastatin. 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid ras homolog family member A Rattus norvegicus