Pub. Date : 2019 Jul 31
PMID : 31368504
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization. | Valproic Acid | ATP binding cassette subfamily C member 2 | Rattus norvegicus |
| 2 | Mechanistic studies suggested that valproate inhibited canalicular trafficking of Mrp2. | Valproic Acid | ATP binding cassette subfamily C member 2 | Rattus norvegicus |
| 3 | This effect of valproate on Mrp2 appeared to be selective in that valproate had less impact on canalicular levels of the bile salt export pump (Bsep) and no detectable effect on P-glycoprotein (P-gp) canalicular levels. | Valproic Acid | ATP binding cassette subfamily C member 2 | Rattus norvegicus |
| 4 | This effect of valproate on Mrp2 appeared to be selective in that valproate had less impact on canalicular levels of the bile salt export pump (Bsep) and no detectable effect on P-glycoprotein (P-gp) canalicular levels. | Valproic Acid | ATP binding cassette subfamily C member 2 | Rattus norvegicus |
| 5 | These findings reveal that two novel mechanisms may contribute to valproate hepatotoxicity: impaired canalicular trafficking of Mrp2 and disruption of ZO2-associated hepatocyte polarization. | Valproic Acid | ATP binding cassette subfamily C member 2 | Rattus norvegicus |