Pub. Date : 2019 Sep 15
PMID : 31362921
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pyrroline-5-carboxylate reductase 1 (PYCR1) is the final enzyme involved in the biosynthesis of proline and has been found to be upregulated in various forms of cancer. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 2 | Pyrroline-5-carboxylate reductase 1 (PYCR1) is the final enzyme involved in the biosynthesis of proline and has been found to be upregulated in various forms of cancer. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 3 | Due to the role of proline in maintaining the redox balance of cells and preventing apoptosis, PYCR1 is emerging as an attractive oncology target. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 4 | We report the design and synthesis of the first tool compounds as PYCR1 inhibitors, derived from pargyline, which were assayed to assess their ability to attenuate the production of proline. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |