Title : A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients.

Pub. Date : 2019 Jul 30

PMID : 31358058






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Our recent study indicates that Casp2-catalyzed tau cleavage at aspartate 314 (tau 2N4R isoform numbering system) mediates synaptotoxicity, cognitive deficits and neurodegeneration in cellular and mouse models of frontotemporal dementia; further, levels of Deltatau314, the soluble, N-terminal cleavage product, are elevated in individuals with mild cognitive impairment and Alzheimer"s disease, compared with cognitively normal individuals. Aspartic Acid microtubule associated protein tau Homo sapiens
2 Our recent study indicates that Casp2-catalyzed tau cleavage at aspartate 314 (tau 2N4R isoform numbering system) mediates synaptotoxicity, cognitive deficits and neurodegeneration in cellular and mouse models of frontotemporal dementia; further, levels of Deltatau314, the soluble, N-terminal cleavage product, are elevated in individuals with mild cognitive impairment and Alzheimer"s disease, compared with cognitively normal individuals. Aspartic Acid microtubule associated protein tau Homo sapiens