Title : Hepatic deficiency of Poldip2 in type 2 diabetes dampens lipid and glucose homeostasis.

Pub. Date : 2019 Oct

PMID : 31351995






2 Functional Relationships(s)
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1 Importantly, the moderate induction of H2O2 in livers dramatically improved the hepatic PI3K-C1/AKT signaling or dampened PI3K-C2gamma/AKT signaling through suppression of PTEN and PTP1B activities, thereby inhibiting the hepatic expression of HMGCR and SREBP2 for cholesterol synthesis. Hydrogen Peroxide thymoma viral proto-oncogene 1 Mus musculus
2 Importantly, the moderate induction of H2O2 in livers dramatically improved the hepatic PI3K-C1/AKT signaling or dampened PI3K-C2gamma/AKT signaling through suppression of PTEN and PTP1B activities, thereby inhibiting the hepatic expression of HMGCR and SREBP2 for cholesterol synthesis. Hydrogen Peroxide thymoma viral proto-oncogene 1 Mus musculus