Pub. Date : 2019 Sep
PMID : 31347748
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Caspase-3-mediated GSDME activation contributes to cisplatin- and doxorubicin-induced secondary necrosis in mouse macrophages. | Cisplatin | caspase 3 | Mus musculus |
| 2 | Besides, cisplatin administration depleted peritoneal macrophages in mice, which was associated with caspase-3 activation and GSDME-NT generation. | Cisplatin | caspase 3 | Mus musculus |
| 3 | CONCLUSION: Chemotherapeutic cisplatin and doxorubicin exerted their cytotoxicity on macrophages partly by inducing caspase-3/GSDME-mediated secondary necrosis. | Cisplatin | caspase 3 | Mus musculus |