Title : Doxorubicin and liposomal doxorubicin induce senescence by enhancing nuclear factor kappa B and mitochondrial membrane potential.

Pub. Date : 2019 Sep 1

PMID : 31340166






1 Functional Relationships(s)
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1 KEY FINDINGS: Based on the results, the highest doses of Dox and Ldox (0.75 and 0.1 mg/kg/BW respectively) significantly increased the level of inflammatory markers and according to other factors especially p53 and SA beta-gal expression, both were able to induce senescence but the changes in Ldox were less tangible than the Dox. Doxorubicin tumor protein p53 Homo sapiens